The Jays edged the O's 3-2 in 10 innings.
Aaron Hill's sacrifice fly in the bottom of the 10th drove in Vernon Wells for the winning run.
Toronto took 2 of 3 against Baltrimore over the weekend but remain 7 games back of Seattle in the chase for the American League Wildcard.
The Jays open up a 3 game series against Oakland at Rogers Centre this afternoon.
Toronto send 10-4 Shawn Marcum to the mound.
You can listen to the broadcast starting at 5 on your voice of the Blue Jays AM 1190.
For all your Jays information go online to www.torontobluejays.com